Enhancing the Stability of a Famotidine Tablet Formulation through the Use of Starch
نویسنده
چکیده
G. LaBella, K. Hughes Colorcon, Inc. Purpose To evaluate the influence of Starch 1500 on physical and chemical stability of a formulation containing a moisture sensitive active with a well characterized degradation pathway due to hydrolysis. Methods To fully assess Starch 1500 in a formulation versus a lactose based formulation currently on the market, three individual studies were conducted: 1. evaluating basic API-excipient compatibility, 2. an open dish stability of four different core formulations and 3. a blister packaging stability study comparing two formulations.
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